Brain Tumor Microenvironment and Host State: Implications for Immunotherapy
نویسندگان
چکیده
منابع مشابه
O 25: Immunotherapy for Brain Tumor
In 1890, Coley observed that cancer patients who developed infections had smaller tumors. From this, he developed Coley’s toxin and treated tumors with injections of infectious materials. In 1960s, Mahaley used monoclonal antibodies to treat central nervous system(CNS) tumors, that research and clinical investigations in brain tumor immunotherapy became a serious undertaking. ...
متن کاملo 25: immunotherapy for brain tumor
in 1890, coley observed that cancer patients who developed infections had smaller tumors. from this, he developed coley’s toxin and treated tumors with injections of infectious materials. in 1960s, mahaley used monoclonal antibodies to treat central nervous system(cns) tumors, that research and clinical investigations in brain tumor immunotherapy became a serious undertaking. there are severa...
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The critical role of angiogenesis in promoting tumor growth and metastasis is strongly established. However, tumors show considerable variation in angiogenic characteristics and in their sensitivity to antiangiogenic therapy. Tumor angiogenesis involves not only cancer cells but also various tumor-associated leukocytes (TALs) and stromal cells. TALs produce chemokines, cytokines, proteases, str...
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Monoclonal antibody (mAb) therapy against tumor antigens expressed on the tumor surface is associated with clinical benefit. However,many tumor antigens are intracellularmolecules that generallywould not be considered suitable targets formAb therapy. In this study, we provide evidence challenging this view through an investigation of the efficacy of mAb directed against NY-ESO-1, a widely expre...
متن کاملThe brain tumor microenvironment.
High-grade brain tumors are heterogeneous with respect to the composition of bona fide tumor cells and with respect to a range of intermingling parenchymal cells. Glioblastomas harbor multiple cell types, some with increased tumorigenicity and stem cell-like capacity. The stem-like cells maybe the cells of origin for tumor relapse. However, the tumor-associated parenchymal cells such as vascula...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2019
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-18-1627